Nature-inspired design and evolution of anti-amyloid antibodies

Designing and Creating a Mouse Using Nature-Inspired Shapes

Human beings have always made their tools and instruments they need using patterns in nature. Mimicking nature has become the foundation of a new science called Biomimetics. In the present article, multiple forms and levels in nature were utilized to design and create a mouse. The rivers are a good source for choosing the shape of a mouse with lots of stones abraded through the centuries which ...

Nature-Inspired Informatics for Telecommunication Network Design

The speedy pace of change in telecommunications and its ubiquitous presence have drastically altered the way people interact, impacting production, government, and social life. The infrastructure for providing telecommunication services must be continuously renewed, as innovative technologies emerge and drive changes by offering to bring new services to the end users. In this context, the probl...

Generation and Characterization of Anti-AA Amyloid-Specific Monoclonal Antibodies

AA amyloidosis results from the pathologic deposition in the kidneys and other organs of fibrils composed of N-terminal fragments of serum amyloid A protein (SAA). Given that there are only limited means to visualize these deposits, we have developed a series of mAbs, 2A4, 7D8, and 8G9, that bind specifically with nanomolar affinity to a carboxy-terminal epitope generated following proteolysis ...

Nature of creative analogies in biologically inspired innovative design

Analogical Problem Evolution In Biologically Inspired Design

Conceptual design typically entails co-evolution of the design problem and the design solution: Initial problem formulations lead to preliminary solutions; Incremental changes in the proposed solution lead to new insights into the design problem, and so on. In this paper, we describe a complementary process: problem evolution using analogies to already existing design cases. In particular, we p...